Delayed Dilated Cardiomyopathy as a Manifestation of Neonatal Lupus: Case Reports, Autoantibody Analysis, and Management

Abstract

Experience and Reason| May 01 1997 Delayed Dilated Cardiomyopathy as a Manifestation of Neonatal Lupus: Case Reports, Autoantibody Analysis, and Management Elizabeth Taylor-Albert, MD; Elizabeth Taylor-Albert, MD Search for other works by this author on: This Site PubMed Google Scholar Morris Reichlin, MD; Morris Reichlin, MD Search for other works by this author on: This Site PubMed Google Scholar Warren H. Toews, MD; Warren H. Toews, MD Search for other works by this author on: This Site PubMed Google Scholar Edward D. Overholt, MD; Edward D. Overholt, MD Search for other works by this author on: This Site PubMed Google Scholar Lela A. Lee, MD Lela A. Lee, MD Search for other works by this author on: This Site PubMed Google Scholar Reprint requests to (E.T.-A.) Oklahoma Medical Research Foundation, Mail Stop 24, 825 NE 13th St, Oklahoma City, OK 73104. Pediatrics (1997) 99 (5): 733–735. https://doi.org/10.1542/peds.99.5.733 Article history Received: July 08 1996 Accepted: October 15 1996 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Elizabeth Taylor-Albert, Morris Reichlin, Warren H. Toews, Edward D. Overholt, Lela A. Lee; Delayed Dilated Cardiomyopathy as a Manifestation of Neonatal Lupus: Case Reports, Autoantibody Analysis, and Management. Pediatrics May 1997; 99 (5): 733–735. 10.1542/peds.99.5.733 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search toolbar search search input Search input auto suggest filter your search All PublicationsAll JournalsPediatricsHospital PediatricsPediatrics In ReviewNeoReviewsAAP Grand RoundsAAP NewsAll AAP Sites Search Advanced Search Topics: antibodies, autoantibodies, cardiomyopathy, dilated, neonatal lupus erythematosus, sjogren's syndrome a antibody, united states social security administration, cardiomyopathy, echocardiography, dilution technique Neonatal lupus erythematosus (NLE) is a transient disease consisting of one or more of the following findings: congenital complete heart block with or without congestive heart failure, photosensitive erythematous macular cutaneous lesions, thrombocytopenia, and cholestatic liver disease.1 In almost all cases, mothers of infants who have NLE have anti-Ro/Sjögren's Syndrome A antigen (Ro/SSA) autoantibodies of the immunoglobulin G (IgG) class. NLE is believed to be caused by the placental transmission of these maternal autoantibodies. The heart block typically begins during the second or third trimester. Although the disease process of NLE is transient, the atrioventricular node may be replaced by scar tissue, resulting in permanent heart block. In those infants who have heart block accompanied by heart failure, pacemaker placement is necessary and is usually sufficient to resolve symptoms. However, at least 10% of infants who have heart block due to NLE have heart failure that does not respond... You do not currently have access to this content.