Selective Cleavage of a 35‐mer Single‐Stranded DNA Containing the Initiation Codon of the TAT Gene of HIV‐1 by a Tailored Cationic Manganese Porphyrin

Abstract

The recognition and cleavage of DNA is highly selective when the cleaver is the conjugate from the chemical nuclease 1 and a 19-mer vector. This is shown on a 35-mer complementary DNA target, which contained the initiation colon of HIV-I TAT. Such reactive antisense oligonucleotides invite further investigation as potential antiviral agents. M = MnIII(H2O), X = O(CH2)4C(O)H, R = N = methylpyridinio.