Studies Towards the Synthesis of Azadirachtin: Enantioselective Entry into the Azadirachtin Framework through Cascade Reactions

Abstract

The carbon framework of azadirachtin (1) has been prepared enantioselectively: The synthesis of compounds 2 a–c follows two novel cascade sequences based on intramolecular radical reactions and acid-mediated redox chemistry. Such advanced intermediates should allow access to 1 through appropriate functional-group manipulations.