Refining Histotripsy: Defining the Parameter Space for the Creation of Nonthermal Lesions With High Intensity, Pulsed Focused Ultrasound of the In Vitro Kidney

Abstract

In an in vitro model we defined the ultrasound parameter region within which purely cavitational ablation of tissue is possible with a negligible thermal component. Additional research is needed to optimize the parameters for in vivo cavitational tissue ablation, incorporating the influence of tissue perfusion.