Synthesis of 4‐dihydroxyboryl‐2‐[¹⁸F]fluorophenylalanine with relatively high‐specific activity

Abstract

Abstract An alternative procedure to produce 4‐dihydroxyboryl‐2‐[ 18 F]fluorophenylalanine ([ 18 F]FBPA) for positron emission tomography studies in boron neutron capture therapy is described. Relatively high‐specific activity electrophilic radiofluorine is produced using a post‐target conversion of [ 18 F]F – to [ 18 F]F 2 . Liquid chromatography with mass spectrometric detection is used to estimate the specific radioactivity of [ 18 F]FBPA and to verify the quality control for chemical identity of the target compound. [ 18 F]FBPA produced according to this method fulfilled the pharmaceutical quality requirements for an injection in patients. Copyright © 2002 John Wiley & Sons, Ltd.