Prolonged Infusion Antibiotics for Suspected Gram-Negative Infections in the ICU: A Before-After Study

Abstract

Routine use of prolonged infusion of time-dependent antibiotics for the empiric treatment of gram-negative bacterial infections offers no advantage over intermittent infusion antibiotic therapy with regard to treatment success, mortality, or hospital length of stay. These results were confirmed after controlling for potential confounders in a multivariate analysis.