Publication | Closed Access
The Art and Science of Total Synthesis at the Dawn of the Twenty-First Century
591
Citations
0
References
2000
Year
Twenty-first CenturyBioorganic ChemistryEngineeringOrganic ChemistrySystem SynthesisChemistryNew MilleniumBiosynthesisSustainable SynthesisNatural ProductsDesignTotal SynthesisSound SynthesisSynthesis MethodNatural Product SynthesisBiomolecular EngineeringIndustrial DesignNatural SciencesModel SynthesisProgram SynthesisSynthetic Chemistry
A new millenium has begun-grounds enough to question the present state of the total synthesis of natural products. In this review we answer this question by tracing the evolution of this fine art and science from its birth to the present time. This retrospective on total synthesis should serve to demonstrate how far we have come, yet show that the science of total synthesis is still in its infancy.