The Molecular Physiology of Sodium- and Proton-Coupled Solute Transporters

Abstract

The expression of cloned Na(+)- and H(+)-coupled solute transporters in Xenopus laevis oocytes has permitted detailed molecular and biophysical analysis and illuminated unique mechanistic features. The identification of missense mutations in inherited diseases and site-directed mutagenesis studies have enhanced our understanding of their roles in physiological and pathological processes.