Experience with Cefazolin: An Overall Summary of Pharmacologic and Clinical Trials in Man

Abstract

A new parenterally administered semisynthetic cephalosporin with a broad spectrum of antibacterial activity, cefazolin, has been shown to be effective in adults and children against infections caused by a variety of gram-positive and gramnegative bacteria. Levels of cefazolin in serum are two to three times higher than those following equal doses of cephaloridine or cephalothin. Cefazolin is generally well. tolerated when administered by the im or iv route and, thus far, has proved to be relatively free from significant side effects.