Fluoroform‐Derived CuCF₃ for Low‐Cost, Simple, Efficient, and Safe Trifluoromethylation of Aryl Boronic Acids in Air

Abstract

Easy does it: Aryl boronic acids undergo smooth and selective trifluoromethylation with low-cost fluoroform-derived CuCF(3) in DMF in non-dried air. The reaction occurs under mild conditions (1 atm, room temperature), exhibits unprecedented functional-group tolerance, and affords trifluoromethylated aromatic compounds in up to 99 % yield.