Concepedia

CSPG4 Protein as a New Target for the Antibody-Based Immunotherapy of Triple-Negative Breast Cancer

Xinhui Wang, Takuya Osada, Yangyang Wang, Ling Yu, Koichi Sakakura, Akihiro Katayama, James B. McCarthy, Adam Brufsky, Mamatha Chivukula, Thaer Khoury,

JNCI Journal of the National Cancer Institute · 2010 · 177 citations · 59 references

DOIFull text

Open access

Abstract

This study identified CSPG4 as a new target for TNBC. The antitumor activity of CSPG4-specific mAb was mediated by multiple mechanisms, including the inhibition of signaling pathways crucial for TNBC cell survival, proliferation, and metastasis.

References

59

Molecular portraits of human breast tumours

Charles M. Perou, Thérese Sørlie, Michael B. Eisen et al. · Nature · 2000 · 16.1K citations

, , +5

Prospective identification of tumorigenic breast cancer cells

Muhammad Al‐Hajj, Max S. Wicha, Adalberto Benito‐Hernández et al. · Proceedings of the National Academy of Sciences · 2003 · 10.3K citations · Full text

Gene expression profiling predicts clinical outcome of breast cancer

Laura van ‘t Veer, Hongyue Dai, Marc J. van de Vijver et al. · Nature · 2002 · 9.5K citations · Full text

, , +9

Repeated observation of breast tumor subtypes in independent gene expression data sets

Thérese Sørlie, Robert Tibshirani, Joel S. Parker et al. · Proceedings of the National Academy of Sciences · 2003 · 5.4K citations · Full text

A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs

Mihaela Crisan, Solomon Yap, Louis Casteilla et al. · Cell stem cell · 2008 · 3.9K citations · Full text

, , +11