Abietane diterpenoid of Salvia sahendica Boiss and Buhse potently inhibits MCF-7 breast carcinoma cells by suppression of the PI3K/AKT pathway

Abstract

Ketoethiopinone and <italic>ortho</italic>-diacetate aethiopinone were identified from the roots of <italic>S. sahendica</italic> and evaluated for their anti-cancer activity in MCF-7 breast cell lines. The type of cell death and the mechanism by which MCF-7 proliferation was limited were investigated.