Oxidized low-density lipoprotein increases superoxide production by endothelial nitric oxide synthase by inhibiting PKC?

Abstract

These results indicate that a decrease in the activity of PKCalpha in ox-LDL-treated endothelial cells is associated with the dephosphorylation of eNOS, dissociation of the eNOS signaling complex, and the enhanced production of eNOS-derived O(2)(-).