Catalyzed Vinylogous Mukaiyama Aldol Reactions with Controlled Enantio‐ and Diastereoselectivities

Abstract

In control: A new catalytic vinylogous Mukaiyama aldol reaction provides products with high diastereo- and enantioselectivities (up to 99 % de and ee; see scheme). The relative and absolute stereochemistry of a representative product was rigorously assigned by NMR and CD spectroscopies (measured and calculated), X-ray diffraction, and quantum-chemical calculations.