Novel 1-hydroxy-1,1-bisphosphonates derived from indazole: synthesis and characterization

Abstract

are an important class of drugs used in the treatment of abnormal calcium metabolism diseases. The first syntheses of bisphosphonates derived from indazole, substituted at the N-1, N-2 and C-3 positions are reported. The 1-hydroxy-1,1-bisphosphonates were synthesized from the corresponding carboxylic acid or acyl chloride compounds, by two different methods. These BPs have a side chain with different lengths ((CH 2 ) n , n = 0-5) between the indazole ring and the bisphosphonate group.