Pd-Catalyzed Diastereo- and Enantioselective [3+2]-Cycloaddition Reaction of Vinyl Epoxide with Nitroalkenes

Abstract

A diastereoselective and enantioselective [3+2]-cycloaddition reaction of vinyl epoxide and nitroalkenes has been developed using Pd/1,1′-ferrocene-<i>P</i>,<i>N</i>-ligand, providing substituted tetrahydrofurans in high yields and with high diastereo- and enantio­selectivities.