Hormonal control of Brunner's glands.

Abstract

In dogs and cats with isolated pouches of the first portion of the duodenum, containing Brunner's glands, the highest rates of secretion, 1.0 ml per 15 min in dogs and 0.7 ml per hr in cats, were attained by ad libitum feeding. Dose-related responses to continuous intravenous infusions of natural or synthetic porcine secretin occurred. Maximal responses to secretin were 0.8 ml per 15 min in dogs and 0.7 ml per hr in cats; the dose required for maximal response was 2 μg per kg-hr in both species. Lower levels of stimulation occurred with histamine, pure porcine gastrin II, pure cholecystokinin-pancreozymin, and pure caerulein.