Stereocontrolled Solid‐Phase Synthesis of Oligonucleoside <i>H</i>‐Phosphonates by an Oxazaphospholidine Approach

Abstract

Stereodefined oligonucleoside H-phosphonates were synthesized on a solid support using diastereopure nucleoside 3′-O-oxazaphospholidine monomers. Several stereodefined backbone-modified analogues were obtained with the oligonucleoside H-phosphonates as precursors (see scheme; BPRO=protected nucleobase, DMTr=4,4′-dimethoxytrityl, Th=thymin-1-yl, TfO−=triflate).