A convenient synthesis of the tetra-aza-macrocyclic ligands trans-[14]-diene, tet a, and tet b

Abstract

A convenient synthesis of 5,7,7,12,14,14-hexamethyl-1,4,8,11-tetra-azacyclotetradeca-4,11-diene (trans-[14]diene) is described. Reduction with sodium borohydride gives the two diastereoisomeric 5,7,7,12,14,14-hexamethyl-1,4,8,11-tetra-azacyclotetradecanes, tet a and tet b, which are readily separated.