Importance of Cytokines, Nitric Oxide, and Apoptosis in the Pathological Process of Necrotizing Pancreatitis in Rats

Abstract

Our results indicate that intraductal taurocholic acid and ischemia-reperfusion provokes severe acute necrotizing pancreatitis with a high mortality rate and leads to systemic inflammatory reaction, which appears to be the consequence of the activation of the cytokine cascade and iNOS. The degree of NO overproduction by iNOS corresponds with the apoptotic process in the pancreas and the lung.