Cancer Research · 2009 · 134 citations · 36 references
Life SciencesCell BiologyMolecular BiologyGene ExpressionSignal TransductionTranscriptional RegulationCancer Cell SignalingCancer Stem Cell MaintenanceCancer Stem CellsHedgehog SignalingSignal Transduction In CancerWnt SignalingCanonical Hedgehog SignalingCanonical Wnt SignalingRna Binding Protein RegulationRna-binding Protein InteractionsWnt In CancerWnt In DevelopmentWnt Signaling In ProliferationWnt Signaling In Stem Cell Maintenance
Wnt and Hedgehog signaling pathways play central roles in embryogenesis, stem cell maintenance, and tumorigenesis. However, the mechanisms by which these two pathways interact are not well understood. Here, we identified a novel mechanism by which Wnt signaling pathway stimulates the transcriptional output of Hedgehog signaling. Wnt/beta-catenin signaling induces expression of an RNA-binding protein, CRD-BP, which in turn binds and stabilizes GLI1 mRNA, causing an elevation of GLI1 expression and transcriptional activity. The newly described mode of regulation of GLI1 seems to be important to several functions of Wnt, including survival and proliferation of colorectal cancer cells.
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Stages of embryonic development of the zebrafish
Charles B. Kimmel, William W. Ballard, Seth R. Kimmel et al. · Developmental Dynamics · 1995 · 12.3K citations
A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
Catherine O′Brien, Aaron Pollett, Steven Gallinger et al. · Nature · 2006 · 4.1K citations
Medicine, Cancer Biology, Oncology +11