Concepedia

A comparative study of mechanical strain, icariin and combination stimulations on improving osteoinductive potential via NF-kappaB activation in osteoblast-like cells

Qiangsong Wang, Xin-Chang Zhang, Ruixin Li, Jinggong Sun, Weihua Su, Yong Guo, Hao Li, Xizheng Zhang

BioMedical Engineering OnLine · 2015 · 16 citations · 34 references

Open access

Abstract

The combination of mechanical strain and icariin stimulation could activate the NF-κB pathway to improve the proliferation, differentiation of osteoblast-like cells.

References

34

NF-κB: Ten Years After

Patrick A. Baeuerle, David Baltimore · Cell · 1996 · 3K citations · Full text

Inflammation, Autoimmune Disease, Disease Mechanism +7

Regulation of bone formation by applied dynamic loads.

Clinton T. Rubin, Lance E. Lanyon · Journal of Bone and Joint Surgery · 1984 · 1.5K citations

In vivo measurement of human tibial strains during vigorous activity

David B. Burr, Charles Milgrom, David P. Fyhrie et al. · Bone · 1996 · 704 citations

Mechanobiology, Physiology, Exercise Physiology +9

Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.

Keith Brown, Suncheol Park, T. Kanno et al. · Proceedings of the National Academy of Sciences · 1993 · 625 citations · Full text

Molecular Regulation, Activated Nf-kappa B, Genetics +21

Mechanotransduction in bone: osteoblasts are more responsive to fluid forces than mechanical strain

Ichiro Owan, David B. Burr, Charles H. Turner et al. · American Journal of Physiology-Cell Physiology · 1997 · 465 citations

Tissue Engineering, Engineering, Biomedical Engineering +19