Rapid Procoagulant Phosphatidylserine Exposure Relies on High Cytosolic Calcium Rather Than on Mitochondrial Depolarization

Abstract

Whether DeltaPsim loss occurs or not, PS exposure is triggered by a high [Ca(2+)](cyt) increase. Data further demonstrate that CsA prevents membrane scrambling by inhibiting the high [Ca(2+)](cyt) increase, independently of its effect on mitochondrial permeability transition pore.