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Synthesis of Substituted 3‐Hydroxy‐<i>1H,5H</i>‐pyrido[1,2‐<i>a</i>]‐benzimidazol‐1‐ones as Possible Antimicrobial and Antineoplastic Agents
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Citations
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References
1984
Year
Organic ChemistryActive Malonates 1Antimicrobial ChemotherapyChemistryHeterocycle ChemistryPharmaceutical ChemistryMedicinal ChemistrySeries 3Antimicrobial Drug DiscoveryDiversity-oriented SynthesisAntimicrobial CompoundPharmacologyAntifungal AgentNatural SciencesImidazoquinolinones 4ASubstituted 3‐Hydroxy‐MicrobiologyMedicineSynthetic ChemistryDrug Discovery
Abstract Syntheses of the title compounds 3 as possible antimicrobial and antineoplastic agents were achieved by reacting the active malonates 1 with the benzimidazoles 2a,b . On the other hand, reaction of 1c,d with 2‐methylbenzimidazole (2c) yielded the imidazoquinolinones 4a,b . Four compounds in the series 3 displayed in vitro antibacterial and antifungal activities.
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