Synthesis of Substituted 3‐Hydroxy‐<i>1H,5H</i>‐pyrido[1,2‐<i>a</i>]‐benzimidazol‐1‐ones as Possible Antimicrobial and Antineoplastic Agents

Abstract

Abstract Syntheses of the title compounds 3 as possible antimicrobial and antineoplastic agents were achieved by reacting the active malonates 1 with the benzimidazoles 2a,b . On the other hand, reaction of 1c,d with 2‐methylbenzimidazole (2c) yielded the imidazoquinolinones 4a,b . Four compounds in the series 3 displayed in vitro antibacterial and antifungal activities.