A New Atropisomeric Molecular Structure for Efficient Enantiodifferentiation

Abstract

Enantioselective clathrate formation and sorption is possible with the enantiomers of the novel atropisomer 1. Racemic 1 is easily accessible from 2,2′-dibromophenyl and fluorenone; the (S)-(+) enantiomer can be obtained pure with (−)-fenchone on formation of the sparingly soluble inclusion complex. Other potential applications are envisaged for these atropisomers in analysis and in asymmetric synthesis.