Direct Intramolecular Arylation of Aldehydes Promoted by Reaction with IPy₂BF₄/HBF₄: Synthesis of Benzocyclic Ketones

Abstract

Iodine helps: Aldehydes acylate arenes upon treatment at low temperature with IPy2BF4 and HBF4. This reaction is exploited in a novel intramolecular approach to the preparation of benzocyclic ketones (see scheme). A plausible mechanistic rational is also given. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z504448_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.