Peripheral blood stem cell transplantation for the treatment of multiple myeloma: biological and clinical implications.

Abstract

Acknowledgments: preparation of this manuscript was supported by grants from Dompe Biotec SpA and Amgen Italia SpA, Milan, Italy. Received January 11, 1996; accepted June 4, 1996. T he aim of this review is to define the role of peripheral blood stem cell transplantation for the treatment of multiple myeloma. Therefore, we first review our present knowledge of this disease and then analyze the clinical trials based on the use of autologous bone marrow or peripheral stem cell transplantation. Optimal methods for peripheral blood stem cell transplantation will also be discussed.