Cognitive impairment in <scp>HIV</scp> infection is associated with <scp>MRI</scp> and <scp>CSF</scp> pattern of neurodegeneration

Abstract

Our results confirm the significant correlation between MRI changes and cognitive impairment in HIV infection. Furthermore, we could show that global brain atrophy and signal changes in basal ganglia are the typical MRI pattern in HAND. The correlation between cognitive impairment and total tau, but not phospho-tau, supports the hypothesis that HAND are not a subtype of Alzheimer's dementia.