Small · 2005 · 330 citations · 7 references
NanoparticlesEngineeringGold ClustersMetal NanoparticlesNanoclusterMolecular BiologyNanotoxicologyAu55 ClustersNanomedicineCellular UptakeToxicologyCancer ResearchCluster ScienceBiochemistryNanobiotechnologyTumor TargetingCell BiologyTumor MicroenvironmentCluster ChemistryMedicineLarger Gold Nanoparticles
Gold clusters (Au55) have been shown to interact with DNA (see image). Armed with this knowledge, experiments have shown that such clusters are shown to have significant toxicity towards many types of human cells, both healthy and cancerous, in contrast to previously studied larger gold nanoparticles. It is hoped, therefore, that there is a future for Au55 clusters in the treatment of certain cancers.
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Gold Nanoparticles Are Taken Up by Human Cells but Do Not Cause Acute Cytotoxicity
Ellen E. Connor, Judith N. Mwamuka, Anand Gole et al. · Small · 2005 · 2.4K citations