A Copper‐Catalyzed Tandem Synthesis of Indolo‐ and Pyrrolo[2,1‐<i>a</i>]isoquinolines

Abstract

Isoquinoline ring the changes: A novel strategy for the title reaction involves ortho-haloarylalkynes which undergo sequential intermolecular addition of N heterocycles onto alkynes and subsequent intramolecular ring closure by arylation. The process involves the use of hydroxymethyl benzotriazole as an efficient and inexpensive ligand for the CN and CC coupling reactions.