Biotechnology and Bioengineering · 1993 · 70 citations · 7 references
EngineeringBiotechnologyChemical EngineeringBiochemical EngineeringBioprocess EngineeringOptimizationBatch FermentationBioprocess OptimizationFed-batch CultureFed-batch FermentationFermentation KineticsProcess OptimizationDynamic Programming PrinciplesFed-batch OptimizationFed-batch Process DesignFermentation OptimizationFermentation Process DesignFermentation Process EngineeringFermentation Process OptimizationState-dependent Constraints
By using penalty functions to handle state constraints, iterative dynamic programming can be used in a straightforward manner for the optimization of fed-batch fermentors. No computational difficulties were encountered and better results are obtained than previously reported in the literature for a fed-batch fermentor for biosynthesis of penicillin.
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