Trideuteriomethoxylation of Aryl and Heteroaryl Halides

Abstract

Abstract Direct access to trideuteriomethoxylated aromatic and heteroaromatic compounds has been developed. Various aryl and heteroaryl halides underwent d 3 ‐methoxylation under mild reaction conditions by using a catalyst system composed of the commercially available monodentate phosphane ligand t BuXPhos and Pd(OAc) 2 . Inexpensive CD 3 OD served as an efficient trideuteriomethoxylating agent.