Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview

Alfred H. Schinkel, Johan W. Jonker · Advanced Drug Delivery Reviews · 2003 · 1.4K citations

Medicine, Biochemistry, Pharmacology +14

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

Alfred H. Schinkel, Els Wagenaar, Carla A.A.M. Mol et al. · Journal of Clinical Investigation · 1996 · 1.3K citations · Full text

Medicine, Pharmacokinetics, Pharmacology +15

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview

Alfred H. Schinkel, Johan W. Jonker · Advanced Drug Delivery Reviews · 2012 · 1.2K citations

Medicine, Biochemistry, Pharmacology +14

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

Alfred H. Schinkel, Els Wagenaar, Liesbeth van Deemter et al. · Journal of Clinical Investigation · 1995 · 1.1K citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

P-Glycoprotein, a gatekeeper in the blood–brain barrier

Alfred H. Schinkel · Advanced Drug Delivery Reviews · 1999 · 954 citations

Medicine, Neuroscience, Pharmacology +8