Concepedia

Combination of EGFR gene copy number and protein expression predicts outcome for advanced non-small-cell lung cancer patients treated with gefitinib

Fred R. Hirsch, Marileila Varella‐Garcia, Federico Cappuzzo, J. McCoy, Lynne Bemis, Ana C. Xavier, Rafał Dziadziuszko, Paul H. Gumerlock, Kari Chansky, Howard West,

Annals of Oncology · 2007 · 270 citations · 43 references

Open access

Concepts

MedicineMolecular GeneticsOncologyCancer GeneticsMolecular OncologyOncogenesCancer BiomarkersCancer GenomicsCancer ProgressionLung CancerMolecular Tumor ProfilingOncogenic Signaling PathwaysEgfr InhibitionEpidermal Growth Factor Receptor InhibitionErlotinib TherapyGene Copy Number AnalysisNon-small Cell Lung Cancer TherapyNon-small Cell Lung Cancer TreatmentProtein Expression Biomarkers

References

43

Global cancer statistics

Ahmedin Jemal, Freddie Bray, Jacques Ferlay et al. · CA A Cancer Journal for Clinicians · 2011 · 55K citations · Full text

Medicine, Oncology, Cancer Epidemiology +15

Global Cancer Statistics, 2002

Donald Maxwell Parkin, Freddie Bray, Jacques Ferlay et al. · CA A Cancer Journal for Clinicians · 2005 · 18.4K citations · Full text

Medicine, Oncology, Cancer Epidemiology +16

New Guidelines to Evaluate the Response to Treatment in Solid Tumors

Patrick Therasse, Susan G. Arbuck, Elizabeth A. Eisenhauer et al. · JNCI Journal of the National Cancer Institute · 2000 · 15.7K citations

Medicine, Oncology, Cancer Pharmacology +12

Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

Thomas J. Lynch, Daphne W. Bell, Raffaella Sordella et al. · New England Journal of Medicine · 2004 · 11.5K citations

Medicine, Oncology, Pharmacology +16

<i>EGFR</i> Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

J. Guillermo Paez, Pasi A. Jänne, Jeffrey C. Lee et al. · Science · 2004 · 9.4K citations

Medicine, Molecular Genetics, Oncology +17