N,N-bis(trimethylysilyl)methoxymethlamine as a convenient synthetic equivalent for +CH2NH2: primary aminomethylation of organometallic compounds

Abstract

The introduction of the primary aminomethyl unit at carbon through N,N-bis(trimethylsily)aminomethylation of Grignard and organolithium compounds can be achieved in good yield using N,N-bis(trimethylsily)methoxymethylamine (1).