Detection of metabolites in the white matter of frontal lobes and hippocampus with proton in first‐episode treatment‐naïve schizophrenia patients

Abstract

The metabolites such as NAA, Cho and MI in white matter of frontal lobes and hippocampus were not significantly altered in FES patients. The lower axonal integrity/number (NAA concentration) may be associated with more severe negative symptoms, and dysmetabolism in process of myelination in the white matter of frontal lobes associated with more severe positive symptoms.