CA A Cancer Journal for Clinicians · 2008 · 695 citations · 110 references
PharmacyBiomedical EngineeringOncologyDrug DeliveryNanomaterialsNanotechnologyCancer Drug DeliveryCancer NanomedicineCell-nanoparticle InteractionsNanocarriers For TherapeuticsNanomaterials For Drug DeliveryNanomedicineCancer ImagingCancer Targeting LigandsMultifunctional NanoplatformsNanoparticle DeliveryNanoparticle Imaging AgentsNanoparticle Imaging ProbesTumor Targeting LigandsTumor-targeted Ligands
Recent developments in nanotechnology have provided researchers with new tools for cancer imaging and treatment. This technology has enabled the development of nanoscale devices that can be conjugated with several functional molecules simultaneously, including tumor-specific ligands, antibodies, anticancer drugs, and imaging probes. Since these nanodevices are 100 to 1,000-fold smaller than cancer cells, they can be easily transferred through leaky blood vessels and interact with targeted tumor-specific proteins both on the surface of and inside cancer cells. Therefore, their application as cancer cell-specific delivery vehicles will be a significant addition to the currently available armory for cancer therapeutics and imaging.
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Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan, Shuming Nie · Science · 1998 · 7.2K citations
In vivo cancer targeting and imaging with semiconductor quantum dots
Xiaohu Gao, Yuanyuan Cui, Richard M. Levenson et al. · Nature Biotechnology · 2004 · 4.7K citations
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Biodegradable Long-Circulating Polymeric Nanospheres
Ruxandra Gref, Yoshiharu Minamitake, Maria Teresa Peracchia et al. · Science · 1994 · 2.9K citations
William J. Gradishar, Sergei Tjulandin, Neville Davidson et al. · Journal of Clinical Oncology · 2005 · 2.1K citations · Full text
Pharmacy, Oncology, Pharmacology +15