Sister Chromatid Exchanges Induced by Behavioral Stress^a

Abstract

Rats subjected to swim stress showed a doubling of sister chromatid exchange (SCE) level. In a second experiment, the generality of SCE induction by behavioral stressors was tested by exposing rats to either swim, white noise, or either continuous or intermittent inescapable footshock stress. The induction of SCEs, although to differing degrees, by qualitatively different stressors, demonstrates that this is a general phenomenon of stress. There may be a cellular genetic basis for some of the effects of stress.