Concepedia

Publication | Open Access

Effects of Orally Active Taxanes on P-Glycoprotein Modulation and Colon and Breast Carcinoma Drug Resistance

DOIFull Paper Access

80

Citations

54

References

2001

Year

Michael Vredenburg, Iwao Ojima, Jean Veith, Paula Pera, Kristin Kee, Fernando Cabral, A. Sharma, Peter M. Kanter, William R. Greco, Ralph J. Bernacki
JNCI Journal of the National Cancer Institute

Abstract

IDN-5109 modulates Pgp activity, resulting in superior tumor growth inhibition against Pgp-expressing tumors as compared with paclitaxel. IDN-5109 may broaden the spectrum of taxane use to include colon tumors.

References

YearCitations

Page 1