DISAPPEARANCE RATE OF CIRCULATING RENIN AFTER BILATERAL NEPHRECTOMY IN THE RAT

Abstract

SUMMARY 1. Plasma renin concentration (PRC) was measured in eight male rats at intervals during a 6 h period after bilateral nephrectomy. 2. PRC fell rapidly, reaching 51% of the mean control level by 10 min, 29% by 30 min, and 2% by 4 h. 3. Under the conditions of the experiment, the half-life of circulating endogenous renin in the rat was about 10 min.