Concepedia

Mutations outside the rifampicin resistance-determining region associated with rifampicin resistance in Mycobacterium tuberculosis

G. G. Siu, Ying Zhang, Terrence Chi‐Kong Lau, Ricky Wing-Tong Lau, Pak‐Leung Ho, Wing‐Wai Yew, Stephen Kwok‐Wing Tsui, Vincent Chi‐Chung Cheng, Kwok‐Yung Yuen, W C Yam

Journal of Antimicrobial Chemotherapy · 2011 · 115 citations · 9 references

DOI

Abstract

Our study showed that amino acid positions 146 and 572 are associated with rifampicin resistance in M. tuberculosis in addition to the RRDR. Molecular assays for identifying rifampicin-resistant M. tuberculosis might be improved in terms of accuracy by including these two positions.

References

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