C1‐Substituted <i>N</i>‐Alkyl Tetrahydroisoquinoline Derivatives through V‐Catalyzed Oxidative Coupling

Abstract

In the THIQ of it: N-Alkyl tetrahydroisoquinolines are oxidatively coupled with a variety of nucleophiles in the presence of m-CPBA and [VO(acac)2]. This method has been applied to the synthesis of the opioid methopholine. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.