Highly Efficient Threonine‐Derived Organocatalysts for Direct Asymmetric Aldol Reactions in Water

Abstract

Abstract The introduction of siloxy groups at the hydroxy function of natural threonine resulted in efficient hydrophobic organocatalysts, which could efficiently catalyze the direct aldol reactions of both cyclic and acyclic ketones with aromatic aldehydes in water with excellent enantiomeric excess.