Efficient Diastereoselective Intermolecular Rhodium‐Catalyzed CH Amination

Abstract

Successful matchmaking: The combination of a chiral nitrene precursor with a chiral rhodium(II) catalyst is the key factor that allows efficient intermolecular regioselective CH amination. Good-to-excellent yields and excellent diastereoselectivities can be obtained with a stoichiometric amount of the CH bond containing substrate. nttl=N-1,8-naphthoyl-tert-leucine.