Journal of Medical Genetics · 1983 · 91 citations · 15 references
Life SciencesGeneticsMolecular GeneticsGenomicsHuman GeneticsMedical GeneticsGene LinkageGene MappingGenetic DisordersGenetic LinkageMendelian DisordersMuscular DystrophyDuchenne Muscular Dystrophy InheritanceGene Mapping In PedigreesGenetic Linkage AnalysisGenetic Linkage MappingGenetic Linkage MapsGenetic PolymorphismsMuscular Dystrophy GeneticsSequence Analysis Of Cloned Genes
A study of DNA restriction fragment polymorphisms and Becker muscular dystrophy has shown eight families informative for the cloned sequence L1.28, which is located on the short arm of the X chromosome between Xp110 and Xp113. Analysis of these families reveals linkage between the two loci, with the maximum likelihood estimate of the genetic distance being 16 centiMorgans (95% confidence limits between 7 and 32 centiMorgans). Since a study of DNA polymorphisms in Duchenne muscular dystrophy has shown a comparable linkage distance with L1.28, our results suggest that the locus for Becker muscular dystrophy, like that for Duchenne dystrophy, is on the short arm of the X chromosome, and further that these two loci may be closely linked or possibly allelic.
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Construction of a genetic linkage map in man using restriction fragment length polymorphisms.
David Botstein, R. White, Mark H. Skolnick et al. · PubMed · 1980 · 8.4K citations