Direct access to isoindolines through tandem Rh(<scp>iii</scp>)-catalyzed alkenylation and cyclization of N-benzyltriflamides

Abstract

The rhodium-catalyzed oxidative alkenylation of N-benzyltriflamides with olefins followed by an intramolecular cyclization via C-H bond activation is described. This method results in the direct and efficient synthesis of highly substituted isoindoline frameworks.