Rh(III)-Catalyzed Selective Coupling of <i>N</i>-Methoxy-1<i>H</i>-indole-1-carboxamides and Aryl Boronic Acids

Abstract

A Rh(III)-catalyzed selective coupling of N-methoxy-1H-indole-1-carboxamide and aryl boronic acids is reported. The coupling is mild and efficient toward diverse product formation, with selective C-C and C-C/C-N bond formation. Kinetic isotope effects studies were conducted to reveal a mechanism of C-H activation and electrophilic addition.