Surfactant protein D and KL-6 serum levels in systemic sclerosis: correlation with lung and systemic involvement.

Abstract

KL-6 is more strongly associated than SP-D with the HRCT-fibrosis score, and, different from SP-D, it correlates with skin involvement and disease activity. We suggest that KL-6 may be a useful biomarker in the assessment of scleroderma patients.