Multifactorial Biological Modulation of Warm Ischemia Reperfusion Injury in Liver Transplantation From Non–Heart-Beating Donors Eliminates Primary Nonfunction and Reduces Bile Salt Toxicity

Abstract

A multifactorial biological modulation eliminates PNF, improves liver function and increases survival. Biochemically, TNF-alpha and redox-active iron are suppressed and biliary bile salt toxicity is reduced. Translating this strategy clinically may lead to wider and safer use of NHBD.