Formulation and evaluation of mixed matrix gastro-retentive drug delivery for famotidine

Abstract

Formulation F(5) was selected as an optimum formulation as it showed more similarity in dissolution profile with theoretical profile (Similarity factor, f(2) = 83.01). The dissolution of batch F(5) can be described by zero order kinetics (r(2) = 0.9914) with anomalous (non-Fickian) diffusion as a release mechanism (n = 0.559). The difference observed in in vitro release profile after temperature sensitivity study at 40°C for 1 month was insignificant.